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Clinical Trials Central Laboratories

April 12, 2022 Life Sciences Review

Awarded as one of the Top 10 Clinical Trial Service Management companies

With state-of-the-art laboratory testing services, next-generation technology, and agile solutions tailored to meet the diverse needs of our clientele around the world, it's no coincidence that Life...

Clinical Trials

December 27, 2021 David Kaye

BioFortis: a data-driven approach to streamlining clinical trial samples

Clinical trials can be envisioned as an ecosystem of laboratories, vendors, and biobanks knitted together by patient samples and data. Tracking patient samples and consent across this highly complex...

Next Generation Sequencing

November 8, 2021 Wendell Jones, Ph.D.

Advancing NGS quality control to enable measurement of actionable mutations in circulating tumor DNA

Cell Reports Methods article authored by Wendell Jones

Clinical Trials Flow Cytometry

November 1, 2021 Megan McCausland

With great power comes great responsibility: high-dimensional spectral flow cytometry to support clinical trials

Spectral Flow Cytometry Special Report

Genomics

August 11, 2021 Wendell Jones, Ph.D.

A benchmarking study of SARS-CoV-2 whole-genome sequencing protocols using COVID-19 patient samples

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging new type of coronavirus that is responsible for the COVID-19 pandemic and the unprecedented global health emergency....

Genomics

April 22, 2021 Wendell Jones, Ph.D.

Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions

BackgroundTargeted sequencing using oncopanels requires comprehensive assessments of accuracy and detection sensitivity to ensure analytical validity. By employing reference materials characterized...

Genomics

April 22, 2021 Wendell Jones, Ph.D.

A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency

BackgroundOncopanel genomic testing, which identifies important somatic variants, is increasingly common in medical practice and especially in clinical trials. Currently, there is a paucity of...

Central Laboratories, End-to-End Services

March 2, 2021 Chuck Drucker

Self-collection of Blood Specimens in Clinical Trials

Blood self-collection or self-sampling devices are in various states of regulatory approval and their utility varies by the amount of blood they can collect, processing requirements by test, and the...

Genomics

January 27, 2021 Patrick Hurban, Ph.D.

High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures

The ToxCast in vitro screening program has provided concentration-response bioactivity data across more than a thousand assay endpoints for thousands of chemicals found in our environment and...

Genomics

January 13, 2021 Wendell Jones, Ph.D.

Dexrazoxane enhances efficacy of all-trans retinoic acid in acute myeloid leukemia patient blast cells and cell lines

All trans retinoic acid (ATRA) has demonstrated curative activity in acute promyelocytic leukemia (APL), a distinct subtype of acute myeloid leukemia (AML), that is characterized by a chromosomal...

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Awarded as one of the Top 10 Clinical Trial Service Management companies

BioFortis: a data-driven approach to streamlining clinical trial samples

Advancing NGS quality control to enable measurement of actionable mutations in circulating tumor DNA

With great power comes great responsibility: high-dimensional spectral flow cytometry to support clinical trials

A benchmarking study of SARS-CoV-2 whole-genome sequencing protocols using COVID-19 patient samples

Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions

A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency

Self-collection of Blood Specimens in Clinical Trials

High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures

Dexrazoxane enhances efficacy of all-trans retinoic acid in acute myeloid leukemia patient blast cells and cell lines