Protein Sciences
Our protein sciences team provides optimized solutions to generate recombinant proteins and antibodies that are customized, well-characterized, quality products for a wide variety of applications. Our broad suite of protein and antibody services are supported by a dedicated team that works closely with you from concept through delivery. You receive proteins tailored to your specifications in scale, purity, activity, and other analytical characteristics — on a timeline that meets your needs.
We welcome complex projects including de novo design, construction, purification, and analytical characterization of novel proteins and antibodies. From pseudo-particles to monoclonal antibodies, our team is experienced in the preparation of immunologic tools and in the purification of a wide range of proteins including large, complex molecules produced in optimal expression platforms. The protein sciences team works as a stand-alone offering or can be integrated with our bioanalytical, vaccine and clinical testing groups utilizing these reagents in a variety of non-clinical and clinical endpoints.
Our approach starts with the customer and their specific needs and goals. Our scientists and operations teams work together to deliver exceptional products in a timely manner while meeting our stringent quality parameters.
Exceptional Science
- Broad experience providing recombinant proteins with high purity, high bioactivity, and high binding affinity
- Different protein expression systems:
- Mammalian cells (expi and CHO cells), baculovirus, yeast, E. coli, cell-free system
- Experience with difficult to expression proteins, including viral, bacterial or human proteins, hetero-oligomers, lipoproteins and particles-forming proteins (VLP, pseudotypes virus)
- Product-specific purification strategies using a combination of techniques with complementary selectivity
- Stringent quality parameters to ensure stability and reproducibility using an orthogonal evaluation of protein related key parameters
Wide-range of protein classes including:
- Amine transferase
- Nitrogenase
- Sialidase
- Protease
- Cystein proteinase
- Viral, bacterial, human proteins
- Intracellular protein
- Integral Membrane protein
- Native protein
- Surface protein
- Complex / multimeric proteins
- Lipoproteins
- Antibodies
- Hetero-oligomer proteins
- Particle-forming proteins (i.e. VLPs)
- Receptor (nicotine acetyl choline)
- Ion channels
Service Expertise
- Flexible and custom solutions to meet your unique needs
- Personalized strategy to ensure quality and consistency of delivered material and best fit to client’s key quality attributes
- Internal processes to ensure scalable products
- Integrated with our bioanalytical, vaccine and other discovery teams
Our Protein Sciences group supports drug discovery and development through:
| Critical Reagent Generation | Characterization | Stability |
| Customized antibody or protein reagents based on client needs | Assessment of critical parameters based on physico-chemical and biological properties using orthogonal approaches | Monitoring key parameters over time |
| Rapid access to custom products | Confirmation of quality, robustness, and reproducibility (key quality attributes) | Rapid detection of any changes in the reagent |
| Certificate of analysis | Reduces project risk |
Our approach helps you reduce costs and expedite discovery.
Related Services & Solutions
Discovery Sciences
Antibody Libraries
In Vitro Immunology
