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Quality FFPE analysis at single cell resolution: elevating single cell RNA sequencing innovation to the next level for optimized drug discovery and development Genomics Q² Solutions Quality FFPE analysis at single cell resolution: elevating single cell RNA sequencing innovation to the next level for optimized drug discovery and development
Authors: Joseph Modarelli, Adam Black and Douglas Wilson
 Advances in Genomic Lab Services Drive Patient-Centered Clinical Trials Genomics David Latto, PhD Advances in Genomic Lab Services Drive Patient-Centered Clinical Trials
As pharmaceutical and biotech companies understand the value of cellular-level insights to further personalize patient care, advancements in genomic laboratory capabilities are growing in interest. ...
 Polyclonal lymphoid expansion drives paraneoplastic autoimmunity in neuroblastoma Genomics Q² Solutions Polyclonal lymphoid expansion drives paraneoplastic autoimmunity in neuroblastoma
Cell Reports article, with contributions from Martin Buchkovich, Q2 Solutions Genomics Highlights
 PLK3 amplification and tumor immune microenvironment of metastatic tumors are linked to adjuvant treatment outcomes in uterine serous cancer Genomics Wendell Jones, Ph.D. PLK3 amplification and tumor immune microenvironment of metastatic tumors are linked to adjuvant treatment outcomes in uterine serous cancer
NAR Cancer article, with contributions from Wendell Jones, PhD, Q2 Solutions GenomicsUterine serous carcinoma (USC), an aggressive variant of endometrial cancer representing approximately 10% of...
 Ultra-deep sequencing data from a liquid biopsy proficiency study demonstrating analytic validity Genomics Wendell Jones, Ph.D. Ultra-deep sequencing data from a liquid biopsy proficiency study demonstrating analytic validity
Scientific Data article, with contributions from Wendell Jones, PhD, Q2 Solutions Genomics
 A benchmarking study of SARS-CoV-2 whole-genome sequencing protocols using COVID-19 patient samples Genomics Wendell Jones, Ph.D. A benchmarking study of SARS-CoV-2 whole-genome sequencing protocols using COVID-19 patient samples
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging new type of coronavirus that is responsible for the COVID-19 pandemic and the unprecedented global health emergency....
 Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions Genomics Wendell Jones, Ph.D. Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
BackgroundTargeted sequencing using oncopanels requires comprehensive assessments of accuracy and detection sensitivity to ensure analytical validity. By employing reference materials characterized...
 A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency Genomics Wendell Jones, Ph.D. A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency
BackgroundOncopanel genomic testing, which identifies important somatic variants, is increasingly common in medical practice and especially in clinical trials. Currently, there is a paucity of...
 High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures Genomics Patrick Hurban, Ph.D. High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures
The ToxCast in vitro screening program has provided concentration-response bioactivity data across more than a thousand assay endpoints for thousands of chemicals found in our environment and...
 Dexrazoxane enhances efficacy of all-trans retinoic acid in acute myeloid leukemia patient blast cells and cell lines Genomics Wendell Jones, Ph.D. Dexrazoxane enhances efficacy of all-trans retinoic acid in acute myeloid leukemia patient blast cells and cell lines
All trans retinoic acid (ATRA) has demonstrated curative activity in acute promyelocytic leukemia (APL), a distinct subtype of acute myeloid leukemia (AML), that is characterized by a chromosomal...