Antibody Discovery Campaigns

Antibody Discovery Campaigns

Specifica

At Specifica, our goal is to generate as many different target-specific antibodies as possible that meet your unique requirements. We have generated more than 100 naïve individual libraries using different scaffolds, formats, variable gene sources and diversity sets.

Using three powerful coordinating technologies

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We first carry out selections from our Generation 3 phage display libraries to obtain an initial pool of antibody leads with maximum diversity.

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Then, we use yeast display to narrow this d

own to a diverse, high affinity fully binding population, reflecting requirements for cross-reactivity, ligand antagonism or additional specificity needs.

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Finally, we evaluate selection outputs with next generation sequencing and AbXtract, Specifica’s next-generation sequencing (NGS) analysis software.

Antibody Clustering

The sequences obtained by NGS are analyzed by machine learning to group antibodies into different clusters expected to bind the same epitope. Our selected antibodies have high affinities, inherently developable biophysical properties and broad diversity, making your transition from lead to drug that much faster.

 

The final product can be a panel of antibodies in any format, or an extensive list of different antibody clonotype sequences you can make and test in house.

Learn what we’re focusing on in the coming months: