Metabolite Profile Comparison Using a HμREL Co-culture Hepatocyte Model versus a Conventional

Determining whether the HμREL model could produce metabolites consistent with those observed in previous human clinical studies

Presented at the 2016 American Society for Mass Spectrometry Annual meeting, this poster details the investigation of four commercially available drugs known to exhibit low metabolic turnover using a conventional hepatocyte suspension and a HμREL co-culture model. We are one of the few bioanalytical laboratories successfully employing immunoprecipitation techniques and multi-dimensional LC for the quantitation of biotherapeutics, peptides, proteins, and biomarkers. Our team has the experience and knowledge in development and validation of small and mid-size peptides to proteins, fusion proteins and monoclonal antibodies. The development of these assays is followed by method validation and sample analysis consistent with global regulatory requirements and governed by SOPs.  Contact us  to learn more about Q2 Solutions and how we can put our tailored solutions, delivery excellence, and shaping outcomes to work for you.

Authors: J. Matthew Hutzler, Richard D. Burton, Shelby Anderson, Xiusheng Miao, Taysir Chamem, David Heim, and Todd Hieronymus

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