Banner Desktop 960 x 350_41

In Vitro Metabolism

The ADME assay development pipeline includes in vitro ADME assays that are necessary once a lead candidate has been selected. The safety profile of a drug candidate will depend partly on its interactions with other drugs, especially those that may be administered concomitantly in standard-of-care treatment. Assessing the risks of possible drug-interactions using validated bioanalytical methods is thus an essential early step in the candidate development process. Q2 Solutions offers a suite of in vitro assays to support drug-drug interaction testing, including cytochrome P450 (CYP) enzyme inhibition (IC50), time-dependent CYP inhibition, induction of CYP enzymes, and CYP reaction phenotyping. All in vitro metabolism assay results are presented in fully QC-reviewed, regulatory-style reports to support filing of IND applications.


Assessing Drug-Drug Interaction Risks

Drug-drug interaction testing provides a definitive assessment of these risks and should be performed early after selection of a lead candidate

Related Services & Solutions

Assessing your Drug-Drug Interaction Testing Risk Assessing your Drug-Drug Interaction Testing Risk

Related Thought Leaders Insights

Scientific Poster Validation of a Stem Cell Assay Used as a Key Efficacy Marker for FDA Approval
Presented at CYTO 2024, the 37th annual Congress of the International Society for the Advancement of Cytometry, May 5-8, 2024 The recent announcement by BiolineRx of the FDA approval of APHEXDA™...
Scientific Poster Spectral Cytometry; a Robust Platform for Immune Monitoring and Biomarker Discovery in Clinical Trials
By Megan McCausland - Scientific Advisor, Flow Cytometry, Biomarker and Translational Science LaboratoryPresented at CYTO 2024, the 37th annual Congress of the International Society for the...
Scientific Poster A new ELISpot/FluoroSpot best practice using a novel lyophilized FBS for clinical immune monitoring assays
Interferon gamma (IFN) ELISpot and FluoroSpot are widely used immune monitoring assays to detect functional cell responses in clinical studies. Recognized for their importance in vaccine development...