Genomic Alterations – DNA & RNA

A comprehensive understanding of the genomic alterations found in your sample is critical to understanding your disease of interest. Q² Solutions has various solutions to help maximize the full value out of your data.

^{*Inquire on availability}

• DNA variant calling is offered across a variety of service types, ranging from small targeted panels on Thermo-Fisher sequencing instruments to Whole Genome Sequencing done on Illumina instruments.
• Our proprietary WES TMB algorithm is one of the few in the industry that can operate with or without a matched normal pair.
• The neoantigen pipeline provides a priority list of candidate targets, assembled by combining our high confidence variant calling with gene expression data.
• Our proprietary Gene Fusion algorithm (STAR-SEQR) is among the most accurate and sensitive algorithms on the market.
• We utilize novel strategies to mitigate the complications associated with RNA Seq variant calling to accurately call variants.

Sensitivity of Gene Fusion Identification

Quantification & Identification

With nearly a decade of NGS experience, Q² Solutions has developed tools and procedures for accurate identification and quantification of data.

• Custom two group comparison methodology providing superior results in comparison to other algorithms publicly available.
• Our Influenza Sequencing pipeline has been demonstrated to be 100% accurate in strain identification.
• ERIC certified IgHV analysis pipeline - Q² Solutions is currently the only lab in North America with this certification.
• HLA calling by either RNA Sequencing or DNA Sequencing with equivalent accuracy.

Customized Services and Signatures

Q² Solutions has extensive experience with custom analyses, including standard Pathway and Gene Set Enrichment Analysis all the way through Biomarker discovery.

• We can generate customized RNA signatures or replicate published RNA Signatures upon request.
• Our Immune Landscape Signatures characterize the activity and type of immune cell infiltrate in the tumor.
• Analysis of treatment response and survival using multiple clinical features or using signatures such as predicted Cytotoxic Immune Infiltration.