This study, conducted to facilitate quick and reliable generation of metabolism data, describes the successful use of a ³H-TA (bearing a tricyclic structure) in an in vivo ADME study during the transition between Discovery and Development. The study was abbreviated because only one bile-duct cannulated (BDC) dog with a single IV dose was used. If the 3H-label is positioned at a stable site, it can be used successfully for a full ADME study, as in the case of a semi-synthetically prepared macrolide, [3H]-emamectin benzoate.

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