Application of an Abbreviated Radiolabeled ADME Study Utilizing 3H (tritium)-labeled Test Article

ISSX 2019 Scientific Poster

This study, conducted to facilitate quick and reliable generation of metabolism data, describes the successful use of a 3H-TA (bearing a tricyclic structure) in an in vivo ADME study during the transition between Discovery and Development. The study was abbreviated because only one bile-duct cannulated (BDC) dog with a single IV dose was used. If the 3H-label is positioned at a stable site, it can be used successfully for a full ADME study, as in the case of a semi-synthetically prepared macrolide, [3H]-emamectin benzoate.

Complete the form below to access this scientific poster