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Scientific Poster
August 02, 2019

Application of an Abbreviated Radiolabeled ADME Study Utilizing 3H (tritium)-labeled Test Article in the Transition between Discovery and Development

ISSX 2019 Scientific Poster
This study, conducted to facilitate quick and reliable generation of metabolism data, describes the successful use of a 3H-TA (bearing a tricyclic structure) in an in vivo ADME study during the transition between Discovery and Development. The study was abbreviated because only one bile-duct cannulated (BDC) dog with a single IV dose was used. If the 3H-label is positioned at a stable site, it can be used successfully for a full ADME study, as in the case of a semi-synthetically prepared macrolide, [3H]-emamectin benzoate1.

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