Case Study
Wendell Jones, Ph.D. | May 08, 2019

Deleterious effects of formalinfixation and delays to fixation on RNA and miRNA-Seq profiles

Scientific Reports Article
This paper, published in Scientific Reports, highlights differences in whole transcriptome RNA sequencing (RNA-seq) and miRNA expression profiling that are attributable to formalin-fixation and DTF. This study provides guidance on best-practice methodologies for FFPE tissue handling and processing as well as analytical methods to enable the accurate and reliable detection of clinically relevant expression-related endpoints using NGS- based platforms.

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