Q2 Solutions offers complete large molecule bioanalysis services, including ADME assay development and high-throughput ADME screening services, DMPK services, and other liquid chromatography mass spectrometry services, for testing around the globe and across the product development spectrum. We combine knowledge from the collective services provided by our central labs, bioanalytical and ADME labs network. The result is timely, high-quality, regulatory-compliant data that supports the insights you need to make more informed decisions and instill confidence in your regulatory filings.
Formed in 2008, the LC-MS biologics team at Q2 Solutions is one of the few bioanalytical laboratories successfully employing both triple quadrupole and high-resolution mass spectrometry (HRMS) for biological analyte LC-MS quantitation. We lead the regulated bioanalysis CRO industry in HRMS capacity with 10 validated Quadrupole- Exactive (QE) orbitrap instruments. Extensive nano-LC capabilities together with a highly automated bead-based immunoprecipitation extraction process delivers unparalleled sensitivity and proven reproducibility. These advanced technologies and our depth of experience combine with a collaborative approach to solve your large molecule bioanalytical challenge.
Q2 Solutions offers a full range of services for the development or technical transfer and validation of custom- designed assays and application to study sample testing for PK concentration, immunogenicity and biomarker testing. Ligand binding assays (LBA), typically in the format of immunoassays, are the standard for bioanalytical testing of large molecule drugs. Formats can include use of target, anti-idiotypic antibodies, anti-conjugate, enrichment approaches, and competitive assays depending on drug design and characteristics of the drug and reagents. Platforms including chromogenic ELISA, chemiluminescence, fluorescence and electrochemiluminescence that provide the standard basis for macromolecule drug testing.
Additional services include critical reagent conjugation and characterization, immunogenicity cut point statistical reports.
Q2 Solutions helps customers evaluate in vitro properties and in vivo plasma/tissue exposures to optimize ADME properties for potential drug candidates and assess risk associated with metabolism and drug-drug interactions (DDI).
Q2 Solutions Innovation Laboratories is located in the heart of the dynamic Research Triangle Park and within our global headquarters in Durham, NC, USA. This facility creates an innovative...
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Our new facility, in theworld-renowned Research Triangle Park, is the flagship laboratory for Q2 Solutions. This custom-designed, 160,000-square-foot facility houses a suite of scientific solutions...