Long-Term Disease-Free Survival in High Grade Serous Ovarian Cancer (HGSOC) is Dependent on Immune Microenvironment Characteristics of Primary Tumor

Application of RNA-based immune signatures in predicting disease-free survival

Patient outcome in high grade serous ovarian cancer (HGSOC) has had mixed success in associating the presence of intra-tumoral T cells and an “immunoreactive” subtype using RNA profiling. In particular, the TCGA OV study was not able to correlate expression-related immunogenicity with outcomes. Important factors associated with prognosis and long-term survivors of HGSOC include residual disease after cytoreductive surgery (RDCS), age and disease-stage.

In this poster, we explore 2 hypotheses:

  1. Primary: Primary tumors from HGSOC patients who have long-term disease-free survival (DFS) harbor a more active adaptive immune cell response.
  2. Secondary: The RNA-based immune signatures found following analysis of pan-cancer TCGA solid tumor samples have application to predict survival in independent cohorts od HGSOC and beyond.

Authors: Wendell Jones, Q2 Solutions; Mahrukh Ganapathi, Levine Cancer Institute; Chad Michener, Cleveland Clinic and Ram Ganapathi, Levine Cancer Institute

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