A Comparison of Suspension, Plated Monoculture, and HμREL® Co-Culture Hepatocyte Models for Estimating Intrinsic Clearance of Low-Turnover Drugs

Q2 Solutions offers complete bioanalytical and ADME solutions for testing around the globe and across the product development spectrum.  We combine knowledge from the collective services provided by our central labs, bioanalytical and ADME labs network, as well as integration into Quintiles global early clinical Phase I unit.  

Presented at the 2015 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting, this poster details the Q2 Solutions team’s efforts to compare in vitro hepatocyte models (suspension, plated and Hμrel® co-culture) using the same lot of cryopreserved hepatocytes for calculating intrinsic clearance of low-turnover drugs.

Shelby Anderson, Ph.D.

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