A Long Enduring Stable Primary Hepatocyte Coculture Mode

Intrinsic Clearance and Metabolite Generation

Q2 Solutions offers a full range of bioanalytical and ADME services to deliver reliable data that are consistent with the highest industry standards. Presented at the 2016 Delaware Valley Drug Metabolism Discussion Group meeting in collaboration with Hμrel® corporation, this presentation describes efforts to compare suspension, plated monoculture and Hμrel® co-culture hepatocyte models for estimated clearance of low-turnover drugs and metabolite generation comparisons. It also covers work that was done with Optivia Corporation to develop an integrated approach to more accurately assess cholestatic liability of drugs. 

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J Matthew Hutzler, Ph.D., Director of In Vitro Metabolism, Bioanalytical and ADME Labs