The importance of TMB standardization for diagnostic assays
Standardization of TMB scores by using a common set of reference standards
Tumor Mutational Burden (TMB) is a predictive biomarker for response to immune checkpoint inhibitor therapy. Laboratories routinely measure TMB using a variety of NGS panels, employing different chemistries and informatics algorithms. Standardization of TMB scores by using a common set of reference standards allows for a more direct comparison of results and straightforward interpretation from tests performed in different labs and platforms.
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