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With great power comes great responsibility: high-dimensional spectral flow cytometry to support clinical trials Clinical Trials Flow Cytometry Megan McCausland With great power comes great responsibility: high-dimensional spectral flow cytometry to support clinical trials
Spectral Flow Cytometry Special Report
 A benchmarking study of SARS-CoV-2 whole-genome sequencing protocols using COVID-19 patient samples Genomics Wendell Jones, Ph.D. A benchmarking study of SARS-CoV-2 whole-genome sequencing protocols using COVID-19 patient samples
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging new type of coronavirus that is responsible for the COVID-19 pandemic and the unprecedented global health emergency....
 Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions Genomics Wendell Jones, Ph.D. Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
BackgroundTargeted sequencing using oncopanels requires comprehensive assessments of accuracy and detection sensitivity to ensure analytical validity. By employing reference materials characterized...
 A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency Genomics Wendell Jones, Ph.D. A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency
BackgroundOncopanel genomic testing, which identifies important somatic variants, is increasingly common in medical practice and especially in clinical trials. Currently, there is a paucity of...
 Self-collection of Blood Specimens in Clinical Trials Central Laboratories, End-to-End Services Chuck Drucker Self-collection of Blood Specimens in Clinical Trials
Blood self-collection or self-sampling devices are in various states of regulatory approval and their utility varies by the amount of blood they can collect, processing requirements by test, and the...
 High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures Genomics Patrick Hurban, Ph.D. High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures
The ToxCast in vitro screening program has provided concentration-response bioactivity data across more than a thousand assay endpoints for thousands of chemicals found in our environment and...
 Dexrazoxane enhances efficacy of all-trans retinoic acid in acute myeloid leukemia patient blast cells and cell lines Genomics Wendell Jones, Ph.D. Dexrazoxane enhances efficacy of all-trans retinoic acid in acute myeloid leukemia patient blast cells and cell lines
All trans retinoic acid (ATRA) has demonstrated curative activity in acute promyelocytic leukemia (APL), a distinct subtype of acute myeloid leukemia (AML), that is characterized by a chromosomal...
 Elevating Effective Outcomes with Companion Diagnostics Alan Wookey Elevating Effective Outcomes with Companion Diagnostics
The successful development and commercialization of personalized medicines often necessitate use of companion diagnostics (CDx).
 World Diabetes Day Interview Steven Lobel, PhD, D-ABMLI, MBA, FACB World Diabetes Day Interview
Research and development for potential COVID vaccines and treatments has been at the forefront of the pharmaceutical industry for most of 2020. Because of this, research dedicated to other...
 Pathology's Best Kept Secret Clinical Trials Anatomic Pathology John Cochran, MD, FCAP Pathology's Best Kept Secret
Chief Pathologist John Cochran discusses how clinical trials offer pathologists the opportunity to work at the forefront of diagnostic discovery in this interview from The Pathologist.