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Scientific Poster
June 19, 2016

Rapid Analysis of Ceftriaxone in Human Intestinal Chyme, Human Plasma, and Dog Plasma by HPLC/MS/MS

Three novel LC/MS/MS analytical methods for the quantitation of ceftriaxone in various matrices that were successfully applied in support of clinical and non-clinical studies.
Authors: Todd Lusk, John F. Kokai-Kun, Michael Schlosser, Stacey Zeman, Sara Brady, Thad Yousey, Dan Mulvana

Download our scientific poster to learn about the quantification of ceftriaxone in various matrices to support clinical and non-clinical studies of a novel oral β-lactamase enzyme. We are one of the few bioanalytical laboratories successfully employing immunoprecipitation techniques and multi-dimensional LC for the quantitation of biotherapeutics, peptides, proteins, and biomarkers. Our team has the experience and knowledge in development and validation of small and mid-size peptides to proteins, fusion proteins and monoclonal antibodies. The development of these assays is followed by method validation and sample analysis consistent with global regulatory requirements and governed by SOPs. Learn more about our bioanalytical capabilities including our biomarker and immunoassay  services.
Quantitative Measurement of a Candidate Antibody Therapeutic in Human Plasma by LC/MS/MS using Formic Acid Digestion

Demonstration that a 2% formic acid digestion can produce a selective signature peptide for antibody quantification using nano-LC/MS/MS

Current Best Practices in Commercial Kit Evaluation and Validation for Biomarker Assays

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