Quantitative Measurement of an Antibody Therapeutic in Human Plasma by LC-MS/MS using Formic Acid Digestion.
Lian Shan, Robert M. Sturm, Raymond F. Biondolillo, John E. Buckholz, Barry R. Jones, John R. Perkins, Ryan Faucette, Daniel J. Sexton
Unifying Processes to Measure Entecavir in Human Matrices in Geographically Distinct Laboratories.
Benno Ingelse, Diep Vu-Pham, Karlien Schellekens, Elsa Artola, Christopher W. Binns, Erika L. Clendenning, Rachel L Caminiti, Martin M. Rappleyea, John R Perkins
Using Cyclic Nucleotides to Assess Endogenous Dilution Accuracy as a Measure of Biomarker Selectivity in LC/MS/MS.
John E. Buckholz, Barry R. Jones, Raymond F. Biondolillo, Robert M. Sturm, Philip E. Joyce, Danielle J. Strong, John R. Perkins, Jennifer M. Cox, Bradley L. Ackermann
Accuracy of Endogenous Dilution as a Measure of Biomarker Selectivity: Quantitation of cGMP and cAMP in Human Plasma by LC/MS/MS.
J.E. Buckholz, B.R. Jones, R.F. Biondolillo, P.E. Joyce, D.J. Strong, R. Sturm, J.M. Cox, B.L. Ackermann
Overcoming Triple Quadrupole Selectivity Challenges by Use of High-Resolution Accurate Mass Spectrometry to Enable Sensitive Quantitation of a Small Molecule Therapeutic in Rabbit Plasma.
Daniel Mulvana, Robert Sturm, Chet Bowen, John Buckholz, Raymond Biondolillo, Kathlyn McCardle, Chris Evans, Barry Jones
Challenges and Opportunities with Aldehyde Oxidase.
J. Matthew Hutzler
The Use of Ascorbic Acid in Dried Blood Spot Analysis to Prevent Oxidation of Thiorphan.
Drew Sparks and Kirk Knotts
A Comparison of Suspension, Plated Monoculture, and HμREL® Co-Culture Hepatocyte Models for Estimating Intrinsic Clearance of Low-Turnover Drugs.
Todd Hieronymus, J. Matthew Hutzler, Mark VandenBranden, Brian Staton, Barbara Ring, Shelby Anderson, Eric Novik, and Matt Shipton
Bioactivation of Indoles by Human Liver Microsomes with Glutathione as Trapping Agent: Formation of Novel Cyclic Cysteine and Cysteine-Glycine Adducts.
Kai Wang, Richard Burton, and Shelby Anderson
Comparison of HμREL Co-culture Hepatocyte Model to Conventional In Vitro Models for Intrinsic Clearance and Metabolite ID.
Part of Hμrel’s Industry Sponsored Symposium at ISSX.
J. Matthew Hutzler