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J. Matthew Hutzler, Ph.D.
Director of In Vitro Metabolism, Bioanalytical and ADME Labs
With over 14 years of experience in the drug metabolism field, Dr. Hutzler’s research has included characterizing atypical enzyme kinetics for cytochrome P450 enzymes, structure-activity relationships for inhibition of CYP2D6, mechanistic studies to explain inhibition of cytochrome P450 enzymes, extrapolation of in vitro metabolism data for human clearance and pharmacokinetic predictions, and recently, understanding species differences and variability of aldehyde oxidase activity using hepatocytes.  He has published more than thirty articles in peer-reviewed journals and written four book chapters in the areas of drug-drug interactions and drug metabolism. 

Prior to joining Q2 Solutions in 2014, Dr. Hutzler acquired significant experience working in the pharmaceutical industry.  He was a DMPK project lead in drug discovery for five years at Boehringer-Ingelheim Pharmaceuticals, and previously also held a similar position at Pfizer Inc. for five and a half years.

Dr. Hutzler earned his Ph.D. in pharmaceutical sciences from West Virginia University under the direction of Dr. Timothy S. Tracy and completed a post-doctoral fellowship at Pharmacia with Dr. Larry Wienkers.

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